Contact: Department of Oral- Maxillofacial Pathology and Medicine, School of Dentistry, College of Medical Sciences.
Salivary gland tumours (SGTs) are a morphologically diverse group of neoplasms, which may present considerable challenges for the Pathologists and Surgeons regarding diagnosis and treatment. In spite of their heterogeneity, SGTs still show differentiation towards cells that morphologically constitute the normal salivary gland – acinar/luminal cells and myoepithelial/ basal cells. Alpha- Smooth Muscle Actin (α-SMA) is an antibody that recognizes the smooth muscle isoform of actin. It does not detect other actin isoforms. Because of the different level of participation of myoepithelial cells in the formation of salivary gland tumours, a differential expression of α-SMA will be expected among these tumours. This study is therefore aimed at assessing the degree of differential expression of α-SMA among salivary gland tumour types, and the possible diagnostic benefits.
Keywords: Salivary gland tumours, immunohistochemistry, alpha- SMA, expression.