The ubiquitous nature of plastics has raised concerns pertaining to continuous exposure to plastic polymers and human health risks of particular concern is the use of endocrine-disrupting chemicals (EDCs) in plastic production, including Di(2-ethylhexyl) phthalate (DEHP) and Bisphenol A (BPA). The aim of this work is to evaluate the pathological effect of bisephenol a and di(2-etylhexyl)phthalate on weight, liver and liver function parameters of albino wistar rats. The experimental Group I, II, III and IV were administered with of BPA and DEHP daily mixed with rat pellet orally in the morning and evening respectively. The value of total bilirubin, conjugated bilirubin, alanine transaminase and alkaline phosphatase was increase significantly (p<0.05) for group II statistically but no significance difference (P>0.05) in the concentration of aspartate transaminase. There was significant increase (p < 0.05) in the concentration of conjugated bilirubin but no significant difference (p> 0.05) in the concentration of alanine transaminase, alkaline phosphatase, total bilirubin and aspartate transaminase in group III in comparison with the control (Table 2). In conclusion the present work reveals that BPA and DEHP can causes severe damage to the liver architectures and significant reduction in body weight .
Keywords: Liver, kidney, Bisephenol A, Di (2-ethylhexyl)phathalate